Pharvaris – Hereditary Angioedema

Berndt Modig, CEO, and Dr. Jochen Knolle, CSO, discuss Pharvaris, a clinical-stage company focused on developing oral therapies for hereditary angioedema (HAE) patients. Hereditary angioedema is a rare and potentially life-threatening genetic condition with incidence between 1 in 10,000 and 1 in 50,000 people. Current therapies are limited by invasive routes of drug administration (injection or infusion), inconvenient dosing regimens, or undesired side effects.

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2019 C3 Prize Winner

Returning guest Bill Rancic is joined by his wife Giuliana to discuss Giuliana’s experience with cancer and how Bill’s role as a caregiver served as the impetus for them to partner with Astellas Oncology on the C3 Prize (Changing Cancer Care), an annual competition to identify creative ideas to improve the lives of people touched by cancer.  They discuss the winners and how the grants (totaling $200K) and resources (professional TEDMED Coaching) will be used to bring the ideas to life and they talk about their latest projects.

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Transitioning from physician to CMIO

Young MDs getting into the field are expressing more and more interest in their job options, including the role of chief medical informatics officer, according to Benjamin Kanter, MD, CMIO of Vocera. That may be the result of daily stories on clinician burnout, or the exciting digital transformation happening in healthcare. Dr. Kanter joins us today to discuss his journey from practicing physician to CMIO. He often consults with medical students about merging their passions for IT and medical school. Often, such students only hear about traditional physician roles – and never about physicians as administrators, or physicians as tech innovators. Dr. Kanter believes that has to change.

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The growing physician shortage and the importance of IMGs

Forensic pathologist, Dr. Bennet Omalu, the man behind the movie “Concussion” discusses his experience as an International Medical Graduate (IMG).  He is joined by returning guest, Dr. William Pinsky, President, and CEO of the Educational Commission for Foreign Medical Graduates (ECFMG®) who will discuss the growing physician shortage and the importance of IMGs to meeting U.S. and global health care needs.

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KLEO Pharmaceuticals developing cancer therapeutics

Returning guest Dr. Doug Manion’s current work developing cancer therapeutics has been uniquely informed by his connections to family and friends who have suffered from the disease. While his drug development work began with HIV therapies, the last 10 years of his career have focused on cancer therapies. Dr. Manion joined Kleo Pharmaceuticals in 2017. Kleo is a unique immune-oncology company developing next-generation bispecific compounds designed to emulate or enhance the activity of biologics. The company’s mission is to create fully synthetic compounds that recruit the immune system to destroy cancer cells, but with significant advantages compared to biologics. Kleo’s small molecule and synthetic peptide compounds function similar to highly complex biologics, yet offer enhanced versatility, improved safety, and efficacy and are faster and cost less to develop. Kleo’s lead compound is expected to commence human studies in 2020.

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The link between inadequate sleep & inadequate nutrient intake

Dr. Susan Mitmesser, VP of Science and Technology at Pharmavite, LLC, maker of Nature Made vitamins and supplements discusses a study published in MDPI that showed a significant association between the prevalence of getting less than seven hours of sleep and the inadequate intake of several micronutrients, including calcium, magnesium and vitamin A, C, D, and E.

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Energy Focus – LED Technology for Healthcare

John Davenport, Chief Scientist of Energy Focus, discusses fluorescent lighting and first-generation LED lights and how the flicker can affect us and may also interfere with hospital equipment.  He discusses the recent advances in LED lighting that is flicker-free and the advantages of having fluorescent lighting retrofitted with state of the art LED lighting. The LED lighting is also poised to transform ordinary environments into smart environments as health care institutions adopt the Internet of Things (IoT) across their facilities.

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Plastic surgery treatment options for breast cancer

October is Breast Cancer Awareness Month and Dr. Elliot Hirsch, Board Certified Plastic Surgeon and The Chief of Plastic Surgery at Providence Cedars-Sinai Tarzana Medical Center, discusses whether a breast cancer diagnosis will require surgery or if there are other options, current treatments, and what women and men can do to improve the healing process. He also discusses what can be done to prevent a dangerous diagnosis.

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