NAD+: Healthy Ageing & Addiction Treatment [transcript][audio]

Guest: Dr. Jeremy Cumpston

Presenter: Tabetha Moreto

Guest Bio: Dr. Jeremy Cumpston has been a general practitioner for some 28 years. He has a special interest in Anti-Ageing and Men’s health and has worked in the past as a men’s health physician. Dr. Cumpston graduated from Adelaide University in 1990 and has worked as a general practitioner for some 28 years. He has had a special interest in Anti-Ageing and Men’s health and has, in the past worked as a men’s health physician at the renowned St Vincent’s Private Clinic in Sydney’s Eastern Suburbs. He has been following the work of Dr Ross Grant and his team in the field of NAD research for the last three years with a particular interest in its applications to treating addiction. Dr. Cumpston is the great grandson of John L. Cumpston, first Australian Chief Medical Officer and founder of the Australian Department of Health.

Segment Overview: In today’s interview, Dr. Jeremy Cumpston joins the program and explains about NAD+, an amazing compound that helps those struggling with addiction and mental health issues such as PTSD. He also talks about the benefits of NAD+.


Tabetha Moreto: Hello everyone, welcome to Health Professional Radio. I’m your host for today Tabetha Moreto. Our guest today is Dr. Jeremy Cumpston who has been a general practitioner for some 28 years. He has a special interest in anti-aging and men’s health and has worked in the past as a men’s health physician. Today, we’re going to talk about something interesting. Something called NAD+, a compound that helps those struggling with addiction and mental health issues. Without further ado, welcome to the show Jeremy, it’s very nice to have you here.

Dr. Jeremy Cumpston: Thank you Tabetha, it’s nice to be here too.

T: Yes, my pleasure. So Jeremy, please tell the audience more about yourself and the nature of your work.

C: So as you said, I’ve been a general practitioner for a life sentence of 28 years and a half. I’ve always had a keen interest in I don’t know I guess in anti-aging and how the body ages and I’ve always at a very keen interest to why, why is this has to happen? Why do we have to? Now I’m 51 now, I wake up every morning and go, “Why is this have to happen to me?” So yes, I have done a lot of research over time, it’s something I do at night because the tendency is to have my brain keep going a bit fast – what some might say “ADD.” But I use research as a means to just sort of like calming my brain down and I just enjoy it. So across along my path of working in anti-aging and men’s health, the research I’ve done I came across some interesting articles about this molecule about “NAD.” NAD is a thing called a “Coenzyme.” Think of it as a vitamin and coenzyme is really a part of every thing or reaction in the cell. NAD provides the energy to the energy’s component to the cell called the mitochondria. And when NAD level decline, we found the mitochondrial energy declines and in fact, the cells die. So over time, you have NAD, this little coenzyme or vitamin in the cell declines because of oxidative stress and life, an injury and as energy declines, the mitochondria decline and then you get cell death. And what happens is, you end up having genetic coding errors happening when you don’t have enough NAD. The genome or the DNA is always under attack from oxidation and from environmental stress and the body is really working very hard to repair that ongoing DNA damage. And NAD is absolutely has been found to be essential in providing the support for the build proteins that repair our DNA. Those proteins are called POPs or CERTs and they’re both interestingly linked to repairing the DNA damage that occurs every single day in all of us, in all of our cells. So we need NAD to make these POPs and Certs to repair our DNA but as we get older and we have increasing damage and oxidative stress, we need more and more NAD and we actually have a declining level. So as our NAD declines, so as our cellular function declines, the communication with the cells decline and the ability for our cells to repair DNA damage declines was leads to damaged DNA coding for conditions like arthritis, or diabetes, or high blood pressure, cholesterol, Alzheimer’s, cancer. DNA damage leads to proteins and physical problems that lead to disease state. So it’s a very unhappy little story I’m telling but basically, the research have shown that the level of NAD in the body is very much correlated to the ability for the body to repair itself. And as NAD levels decline, so to does our ability to repair and therefore we have age-related diseases that ends up the organism ending up failing.

T: Very interesting. Now can you tell us why is this relevant to health professionals?

C: What has been found with NAD and it’s been found over many, many years Tabetha. Right down from the 1920s, NAD was discovered. NAD is a derivative of Niacin, of B3. And so people that weren’t getting enough vitamins particularly bigger environments in their diet, during the sort of Depression Era in the 1920s and 30s was how often people suffer from head disease “psycho pellagra” And that was cause terrible skin conditions, nerve degeneration and eventual death. So what happened was that, there’s a lot of experimentations on it to actually solve this pellagra and they found that by giving them Vitamin B in their food or giving them Iodine infusion of a thing called “NAD” which is a Vitamin B3 derivative would completely resolve this condition of pellagra. So they have known for a long time that NAD is essential for normal neuronal function and normal brain function. So what happened was is that when there treating people with pellagra who happened to also be alcoholic, they found when they were given this NAD, the desire or craving for alcohol was removed and no longer felt the craving. And so they postulated that this NAD, this coenzyme was also a neurotransmitter and it had a very balancing effect on brain neurochemistry. That was taken further in the 60s in South Africa where they started using NAD for alcoholism. And from 1960 until now over 20,000 people that’s been treated using NAD in an oral capsule and there’s been a very successful treatment for alcoholism. In America from basically early 2000, a clinic called the Springfield Wellness Center started using NAD in an IV solution for treating opioid addiction and alcohol addiction. And in over 2,000 people in 20 years, they’ve reported an 85% success rate in assisting people to become free of drugs in their life. And the way that it works is the IV NAD reduces cravings which allows other modalities of therapies such as intensive psychological counselling, diet, nutrition to also work its way to reducing the behavior that led to the alcoholism or the opioid addiction. So it’s been a very exciting new treatment in addiction therapy and that’s what’s really caught my attention. It’s the incredible positive results that we’ve been having using this short term drip of NAD to basically calm with the neurological centers and improve communication, internally leads to a situation where people known to have cravings and are able to give up whatever this substance they are addicted to.

T: Wow, that’s amazing to know that something like NAD+ can help all these people especially with their condition.

C: Yes, because the thing is it can’t be just used on its own though. I mean it’s an important and exciting tool I think to be used into our physicians, psychologists, psychiatrists, nutritionists, sort of kit bag. Something to help people reduce their cravings so that they can actually institute other therapies to help to solve the behavior. Certainly, it’s really hard to change of behavior when someone is craving something. You can’t stop with craving just by willing it away, it doesn’t happen that way. But by removing the craving, you really, really get in there and to try and adjust the behavior that has led to that addiction.

T: Very well said. Now Jeremy if you don’t mind, can I ask you a personal question?

C: Well it depends on what the question is. Yes, go ahead.

T: Okay. Why are you so passionate about anti-aging and men’s health?

C: Well I don’t know, that’s the honest answer. I just always felt that medicine and the way that I was trained was that medicine seem to be somewhat “one-eyed” to me. It’s like you prescribe this medicine for headache and you prescribe this medicine for an infection. It always seemed to me a bit ad-hoc and not really well. For me, it was not really well investigated, described, explained or quantified. I came out of med school and all the doctor and was tend to use a lot of medicines and didn’t really, really going to the detail about how they work or why they’re working. And I’m not sure of that whether they were actually working on the pathogens of the disease or the basic cause of the disease. So I guess that’s what started my interest in research and saying, “Oh, what is the cause of this situation? Why is it these people are getting sick?” Not once they’re sick will we do this. I wanted to know why, why this people are getting sick and I guess that’s been a lifelong sort of, it’s a hobby, it’s something I do at night. I read about things and with the finding out about the NAD, it came to me from someone saying, “This is amazing, brain boost treatment in Harley Street,” my friend who have been there and he said, “It’s amazing. I felt so clear, I felt so calm, I was able to get things done, I think you should really investigate it.” It was from a point of view of someone I really trusted, this was a t close friend of mine. This treatment really worked for him. And I didn’t feel he’d be sucked into the placebo effect. So I started to investigate and so yes, it’s a very big business in Europe and America for using this is a brain boost. But what I really found was that the most important research on the topic of NAD and its relation to oxidative stress in the body and which is really about how the body copes with stress and aging and then what happens to our DNA as we age. All this incredible research was actually coming out of Sydney, Australia down the road from me by an individual called Dr. Ross Grant. He put 20 years of intense research into this molecule and I think it’s really starting to show that his research is going to pay a massive dividends in terms of how we deal with conditions particularly those that are related to neurochemical disorders in humans.

T: Thank you very much Jeremy for sharing your story about your passion for medicine, anti-aging and all of the above.

C: Thank you very much Tabetha and thanks for having us.

T: Yes, my pleasure. Unfortunately Jeremy, we only have a little time left but before we go, what is your main takeaway message to all of our listeners out there? What you would like to tell them?

C: The main takeaway message that I would like them to have a look at NAD, the work of Ross Grant and if they have people or loved ones who are having problems with addiction, be it opiate, methamphetamine or alcohol, then they should look at the potential of NAD IV therapy to assist in getting those people back into a more sober healthy life. I think we’re going to doing research on measuring NAD levels and all the patients we treated, we’re sending that back to Dr. Grant so I’m quite excited by the potential of NAD to be a helpful adjunctive tool in treating mental illness and addiction.

T: Excellent message Jeremy. And one more question – for those who want to get in touch with you, how can they do that?

C: Okay. So the best to probably get in touch is that just send us an email or to go to our website which is and send us an email and I personally respond to it.

T: Fantastic. Thank you so much Jeremy for coming on the show, it was a pleasure having you.

C: Thank you very much Tabetha. I really appreciate it.

T: And that was Jeremy Cumpston, we just had a fascinating conversation about NAD+, a compound found in every cell in your body that plays a vital role in regulating how quickly your cells age. If you like this interview, transcripts and archive are available at We’re on all social media platforms so don’t forget to follow, like and subscribe. We’re also available for download on SoundCloud and iTunes. I’m Tabetha Moreto and you’re listening to Health Professional Radio.

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