Moderate to severe fatigue affects nearly 50% of psoriatic arthritis (PsA) patients and greatly impacts their quality of life. Dr. Alyssa Johnsen, MD, PhD, Vice President, Rheumatology Disease Area Lead, Janssen Research & Development discusses a new publication in “Arthritis Research & Therapy” that supports TREMFYA’s (guselkumab) ability to reduce fatigue in psoriatic arthritis (PsA) patients. The two phase 3 clinical trials of 1,120 patients with active PsA found that guselkumab 100 mg every four weeks or every eight weeks led to clinical and sustained improvements in fatigue through one year.
Alyssa Johnsen, M.D., Ph.D., is Vice President, Rheumatology and Maternal-Fetal Immunology Disease Area Leader for the Immunology Therapeutic Area at Janssen Research & Development, LLC. In this role, Alyssa is responsible for driving scientific leadership in rheumatology and maternal-fetal health, overseeing innovative compounds across multiple phases of development.
Prior to her role at Janssen, Alyssa held clinical development, translational and portfolio leadership roles across Immunology and Oncology at Bristol-Myers Squibb, encompassing both early and late development. She led development of a portfolio of immune-oncology assets from Phase 1 through POC, as well as early registrational trials. Within Immunology, she held a variety of roles including leader of the translational team for a key marketed asset and the leader of the late-phase clinical development group.
Earlier in her career, Alyssa was a faculty member in the Division of Rheumatology at the Brigham and Women’s Hospital and subsequently the University of Pennsylvania, performing basic and translational research in autoimmune diseases as well as caring for rheumatology patients.
Alyssa received her bachelor’s degree in chemistry at Duke University and her Ph.D. in immunology and M.D. at Case Western Reserve University. She completed residency training in internal medicine at the Massachusetts General Hospital and a fellowship in Rheumatology at the Brigham and Women’s Hospital.