The Development of New Therapies that Supplement Vaccines to Aid Vulnerable Communities

Dr. Dorry Segev, Professor of Surgery and Epidemiology and Associate Vice Chair of Surgery at Johns Hopkins University discusses the impact of COVID on the immunocompromised community and the importance of bringing new therapies to patients that supplement vaccines and provide long-lasting protection, including the FDA’s recent decision to authorize AstraZeneca’s COVID long-acting antibody (LAAB) combination named Evusheld (AZD7442), which can provide at least six months of protection against COVID-19 after a single dose. The emergency use authorization of Evusheld is an important step forward for people who may remain vulnerable to COVID-19 because of an inadequate response to a COVID-19 vaccine, including people with blood cancers or other cancers being treated with chemotherapy, and those taking medications after an organ transplant or who are taking immunosuppressive drugs for conditions including multiple sclerosis and rheumatoid arthritis.

Dorry Segev, MD, PhD, is a Professor of Surgery and Epidemiology and Associate Vice Chair of Surgery at Johns Hopkins University. He has published over 700 peer-reviewed research articles, and is ranked #1 worldwide in organ transplantation expertise and influence by ExpertScape. Reflecting his contributions to health care, he was recently elected into the National Academy of Medicine. Reflecting the creativity and broad reach of his contributions, he received a prestigious Global Thinker Award from Foreign Policy Magazine and was named an Innovators of the Year by TIME Magazine. His work has directly influenced policy, including two Congressional bills (the Norwood Act for kidney exchange and the HOPE Act for HIV-to-HIV transplants), and is regularly featured in widely read media including several front-page features in the New York Times. In the context of the pandemic, Dr. Segev shifted his research to better understanding vaccines in the immunocompromised, for which he has received a Letter of Commendation from Dr. Anthony Fauci and a $40 million grant from the NIH.

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