Exact Sciences – Oncotype DX ® Test Can Help Certain Types of Breast Cancer Avoid Chemotherapy

Dr. Jean-Francois Boileau, MD, MSc, FRCSC, surgical oncologist  at Jewish General Hospital Segal Cancer Centre; associate professor of surgery and oncology at McGill University; and director of the JGH Breast Clinical Trials Group discusses the publication of the RxPONDER trial in the “New England Journal of Medicine” that confirms that tens of thousands of women with a certain type of breast cancer can avoid chemotherapy with Exact Sciences‘ Oncotype DX ® Test.   These results, together with the foundational TAILORx results in node-negative, early-stage breast cancer, further elevate the test to a standard of care in a broader patient population. NCCN guidelines have also followed suit and now recognize the Oncotype DX test as the only genomic test that can be used for the prediction of chemotherapy benefits in both node-negative and postmenopausal node-positive women.   

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Exact Sciences – Genomic Prostate Score ® (GPS™) Test and Adverse Pathology

Returning guest, Dr. Rick Baehner, MD, Chief Medical Officer of Precision Oncology at Exact Sciences discusses a new study in “Urologic Oncology: Seminars and Original Investigations” that validates adverse pathology as a predictor of prostate cancer outcomes in clinically low-risk patients. This news supports the utility of the Oncotype DX GPS™ test to manage treatment decisions by showing that the combined risk of adverse pathology is more strongly associated with worse long-term outcomes than the separate risks for high-grade disease and non-organ confined disease alone. 

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The Future of the Digital Health Market in Mental Health

Dr. Murray Zucker, ​MD, ​Chief Medical Officer at Happify Health discusses the technology enhancements and regulatory advancements that could reshape the future of healthcare delivery, such as the continued expansion of telehealth and digital therapies, as well as the ability for licensed mental health clinicians to practice across state lines. He shares his thoughts on treating the body and mind as one, the rise of more holistic medicine, and addresses the comorbidities associated with mental health.​ 

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New Study Explores the Impact of Marijuana Use in Research

Dr. John Kaddis, PhD, Assistant Professor in the Department of Diabetes & Cancer Discovery Science within the Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope, discusses a recent study from City of Hope which found that cells that control blood glucose levels from deceased chronic marijuana users failed to reverse diabetes at a much higher rate than from those who did not use it. This study underlines the importance of considering one’s lifestyle when evaluating human pancreatic islets for transplantation or research. It also aims to encourage other studies around organ donation to consider the implications of lifestyle. 

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Uncovering Shame

Returning guest, Wendi L. Dumbroff, MA, LPC, discusses shame, an issue many suffer with – yet rarely discussed. Shame is a huge issue for it creates the feeling there is something wrong with the person. This is common in people who are survivors of sexual abuse, trauma, or if someone feels unloved by a parent or receives other negative messages from a loved one. ​She provides vital information for anyone who may be suffering in silence. 

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Janssen Establishes New National Biologic Coordinators Day

Nikki Longwell, PhD, Sr. Director, Medical Science Liaisons, Immunology, Janssen, discusses the launch of the first National Biologic Coordinators Day on November 1, 2021 and its importance. She talks about what a biologic coordinator is – working in partnership with the patient, prescribing healthcare providers, specialty pharmacies, manufacturers, and insurance companies to navigate the numerous steps required to get patients started on their prescribed biologic medication.

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Third Pole Therapeutics – eNOfit – First Wearable Drug Making Platform

Bill Athenson, CEO of Third Pole Therapeutics, a privately held company developing critical life-sustaining cardio-pulmonary therapies, discusses eNOfit™ the company’s proprietary, tankless, on-demand, electrically generated inhaled Nitric Oxide (iNO) technology that is a safe, accurate and reliable lightweight, wearable device that makes iNO from electricity and the air we breathe, creating a make it and take therapy free from the hazards of compressed gas storage. Their proprietary, versatile technology has the potential to rapidly capture the entire existing in-hospital tank-based market and expand beyond current indications to treat interstitial lung disease, chronic obstructive pulmonary disease, cystic fibrosis, and critical viral and bacterial infections. eNOfit devices are being tested in preparation for an FDA investigational device exemption (IDE) submission later this year to enable human safety testing to begin in early 2022. 

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Does Excessive Drug Usage Cause Infertility?

Drug abuse can impact fertility but not many people know it.

You might have thought that drug abuse hampers your physical health or your mental health or both but you are forgetting one thing: it causes hormonal imbalance.

When your hormones are not acting right, it may hamper your fertility quotient, and that applies to both men and women.

In fact, studies show almost 30% of people who abuse drugs at reproductive age suffer from fertility issues. Tobacco, drug, and alcohol addiction take a toll on your overall health ratio, and today we will discuss their impact on fertility.

Ascendant NY also sheds light on this matter when they approach drug addiction victims, so it’s time you get full disclosure.

If you want to know more about it, keep scrolling this article and we will get you there.

Let’s Look At Some Statistics…

Misuse of drugs can have a severe impact on fertility, especially in women. In truth, both women and men suffer from infertility as a result of drug and alcohol abuse.

Drug abuse can directly impact fertility by interfering with the body’s reproduction mechanisms. However, because of how drug use and addiction can alter health and lifestyle, it also has an indirect effect. Drug usage can have harmful consequences if a pregnancy is achieved, in addition to harming fertility.

Nicotine and other drugs can negatively affect a pregnant woman and her kid. These unfavorable consequences are more likely to occur during the first three months of pregnancy, when the woman may be unaware that she is pregnant. Given that women with opiate addiction have an unwanted pregnancy rate of up to 86%, this is a severe issue.

Substance abuse disorders are easily detectable in women of childbearing age. Not only that, even children are 13 times more likely to face addiction problems in the future if one of their parents has a history of drug abuse.

Studies show that 55% of women drink alcohol aggressively, 23% smoke and 105 use illicit drugs. It also shows that men who smoke have a 22% reduction in their average sperm production capacity than men who don’t smoke.

A recent study done in the United States shows that more than 60% of men under the age of 35 use illicit substances like cannabis, stimulants, opioids, and anabolic steroids. Moreover, there is also a significant rise in drug usage during the pandemic. So, it proves that drug abuse is a prevalent issue worldwide.

Drug Abuse Impact On Male Fertility

There are many drugs such as synthetic testosterone, anabolic steroids, opiates, marijuana, alcohol, etc that can impact male fertility.

It may happen that some of these drugs are prescribed by your healthcare provider to cure a disease or support your professional career, but if you want to father a child, you must consult a specialist before ingesting them.

There are many non-FDA-approved male fertility supplements, which you should be particularly careful of. They may be promoted as fertility enhancers, but there is no scientific proof to support their claim if the FDA has not approved them.

When you take testosterone supplements, your testicles stop secreting natural testosterone, and the moment you stop taking them, your sperm production stops.

Many athletes and gym enthusiasts take anabolic steroids to build muscle mass. But unfortunately, they don’t know that these steroids reduce your body’s natural ability to produce sperm, which will hamper you in the future.

Drinking alcohol in moderation may not hamper your fertility quotient, but heavy drinkers often face problems like erectile dysfunction. In fact, if you are a smoker, your kid may be born with sudden infant death syndrome.

THC is the active ingredient in marijuana, which helps people get a euphoric high when they need it. However, it also reduces the sexual drive in people and reduces your testosterone production, which impacts your reproductive abilities.

Drug Abuse Impact On Female Fertility

Drugs’ impact on women’s fertility problems is much more complex than men’s.

With men, the only factor is they have to produce healthy sperm, and excessive drug usage can hamper that. However, with women, there are many other factors to consider that may be hindered if the lady abuses drugs and alcohol.

The factors are:

  • Menstrual cycles.
  • Hormone production.
  • Ovulation.
  • The health of the reproductive tract.
  • Condition of the fallopian tubes.
  • Condition of the cervix.
  • Condition of the uterus.

Not only illegal drugs but even legal ones can hamper women’s fertility, which is not a problem for men. Women are likely to get fertility issues even by drinking too much caffeine.

Many women who never drank or smoked had a 50% less chance to conceive a healthy baby just because they drank more than one cup of caffeinated drink every day.

Too much tobacco usage blocks sperm from reaching the egg and thickens cervical mucus. Tobacco use in women can delay the pregnancy period by a year and a half, and it reduces the chance of conceiving a healthy baby in almost 15% of couples.

A recent study showed that 55% of women faced delays in their menstrual and ovulation cycles because of excessive marijuana usage. Opioids impact the hypothalamus and pituitary glands, reducing hormone production. It even impacts the menstrual cycle and causes irregularities there.

Final Verdict

Does excessive drug usage cause infertility?

Of course, it does.

However, these statistics are not dissuading anyone because more and more people are getting addicted to unhealthy substances every day. No matter how many cigarette packets come with a cautionary warning that ‘tobacco causes cancer’, people are still buying them.

Hence, if you want to live a healthy life and give birth to a healthy child in the future, you must stop unhealthy drug usage right away.

As we always say, ‘Better Late Than Never.’ If you quit the habits now, there are chances of you giving birth to a healthy progeny someday.

If you need more help from us, reach us in the comment box below. We will get back to you with an answer shortly.