Final Dataset of Phase 2 ENTRIGUE Trial of Pegozafermin​

Dr. Deepak Bhatt, MD, MPH, Director of Mount Sinai Heart and Principal Study Author discusses the final dataset from the Phase 2 ENTRIGUE trial of 89bio’s pegozafermin in patients with severe hypertriglyceridemia (SHTG) that was published online in “Nature Medicine” (June 24, 2023). To learn more about pegozafermin’s indications in non-alcoholic steatohepatitis (NASH) and severe hypertriglyceridemia (SHTG), please visit https://www.89bio.com/pipeline/.

Deepak L. Bhatt MD, MPH, FACC, FAHA, MSCAI, FESC, is Director of Mount Sinai Heart and the Dr. Valentin Fuster Professor of Cardiovascular Medicine at the Icahn School of Medicine at Mount Sinai Health System.

After graduating as valedictorian from Boston Latin School, Dr. Bhatt obtained his science degree as a National Merit Scholar at MIT. He received his MD from Cornell and MPH from Harvard. He is working on his Executive MBA from Oxford. He trained in internal medicine at the University of Pennsylvania and in cardiology at Cleveland Clinic. He completed fellowships in interventional cardiology and cerebral and peripheral vascular intervention and served as Chief Interventional Fellow at Cleveland Clinic, where he spent many years as an interventional cardiologist, Associate Professor of Medicine, Director of the Interventional Cardiology Fellowship, Associate Director of the Cardiovascular Medicine Fellowship, and Associate Director of the Cardiovascular Coordinating Center. He then served as the Chief of Cardiology at VA Boston Healthcare System and subsequently as Executive Director of Interventional Cardiovascular Programs at Brigham and Women’s Hospital. He was a Senior Investigator in the TIMI Study Group and Editor-in-Chief of the Harvard Heart Letter. He became a full Professor of Medicine at Harvard Medical School in 2012. He was selected by Brigham and Women’s Hospital as the 2014 Eugene Braunwald Scholar. He has been listed in Best Doctors in America from 2005 to 2020. He received the Research Mentor Award from Brigham and Women’s Hospital Department of Medicine in 2016, the Eugene Braunwald Teaching Award for Excellence in the Teaching of Clinical Cardiology from Brigham and Women’s Hospital in 2017, ACC’s Distinguished Mentor Award in 2018, AHA’s Distinguished Scientist Award in 2019, NLA’s Honorary Lifetime Membership Award in 2021, and SCAI’s Master designation in 2022.

Dr. Bhatt has authored or co-authored over 2000 publications and has been listed by the Web of Science Group as a Highly Cited Researcher from 2014 to 2022. He is the Editor of Cardiovascular Intervention: A Companion to Braunwald’s Heart Disease and of Opie’s Cardiovascular Drugs: A Companion to Braunwald’s Heart Disease. He is one of the co-Editors of Braunwald’s Heart Disease. He is the Editor of the Journal of Invasive Cardiology. He had served as Senior Associate Editor for News and Clinical Trials for ACC.org and as a Trustee of the ACC.