Horizon Therapeutics – First Patient In Phase 2 Systemic Lupus Erythematosus Study

Dr. Arezou Khosroshahi​, ​MD, Associate Professor of Medicine at Emory University​ discusses the enrollment of the first patient in Horizon Therapeutics‘ Phase 2 trial to evaluate HZN-7734, ​a first- in-class, fully human monoclonal antibody to treat people with moderate to severely active systemic lupus erythematosus (SLE). SLE is an autoimmune disease where the immune system mistakenly attacks healthy cells and tissues. Of the 5 million people living with a form of lupus, SLE accounts for nearly 70 percent of cases and presents a tremendous unmet treatment need.​

Arezou Khosroshahi is an Associate Professor of Medicine in the division of Rheumatology. She joined Emory in 2012 and founded the IgG4-RD clinic at Emory. This clinic is one of the few in the United States to evaluate and treat patients with IgG4-RD with referral from all around the Southeast. She has been one of the initial investigators interested in understanding IgG4-RD since her fellowship at MGH and has played an important role in naming the disease, developing pathology statement and more recently the classification criteria for the diagnosis of IgG4-RD. She is the co-director of Emory Lupus clinic and has served at Grady Lupus clinic in the past 9 years, taking care of lupus patients in Georgia and working closely with scientists in Emory Lowance Immunology Center in understanding many different aspects of lupus in the diverse population in Atlanta with particular interest in treatment.

She also currently serves as the director of clinical trials at the division of rheumatology at Emory university and has been principal investigator on multiple clinical trials in Lupus and IgG4-RD.

Dr. Khosroshahi received her medical degree from Tehran University Medical School in Iran. After finishing a postdoctoral research fellowship in the Transplantation Center at the Brigham and Women’s Hospital, Harvard Medical School, she completed her internal medicine training at St. Lukes-Roosevelt Hospital Center, Columbia University. She pursued her clinical rheumatology fellowship at Massachusetts General Hospital, where she became involved in clinical research and clinical trial design.

Dr. Khosroshahi has a particular interest in clinical education and works closely with Emory medical students, residents, and fellows at Grady Memorial Hospital and Emory University.

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