FDA Authorizes AstraZeneca’s COVID Antibody Combination for Emergency Use

Returning guest, Dr. Brian Koffman, Executive Vice President and Chief Medical Officer, CLL (chronic lymphocytic leukemia) Society, and a CLL patient discusses the FDA’s Emergency Use Authorization of AstraZeneca’s COVID long-acting antibody (LAAB) combination named Evusheld (AZD7442) developed to provide at least six months of protection against COVID-19 after a single dose.   The news is of particular importance to  people who are immunocompromised or  may remain vulnerable to COVID-19 because of an inadequate response to a COVID-19 vaccine –  such as people  with blood cancers or other cancers being treated with chemotherapy.  Dr. Koffman is one of these people, as he was diagnosed with chronic lymphocytic leukemia (CLL), and is therefore more vulnerable to COVID-19. He is here to discuss the FDA’s decision to bring Evusheld to patients under emergency use, and what it means to people like him.  Dr. Koffman also took part in the PROVENT Phase III trial evaluating Evusheld for prophylaxis. 

Brian Koffman, MDCM, MS Ed

Dr. Koffman, a well-known doctor, educator and clinical professor turned patient, has dedicated himself to teaching and helping the CLL community since his diagnosis in 2005. Dr. Koffman believes that his dual status as a physician and patient provides a unique experience and understanding which allows him to provide clear explanations of complex issues and to advocate for his fellow patients and inform his fellow healthcare providers. This is especially important in view of the rapidly changing therapeutic landscape. Besides his medical degree, Dr. Koffman has a Master of Science in Medical Education. Dr. Koffman is also a retired family doctor, a retired clinical professor in family medicine at the Keck School of Medicine, USC, and the former medical director of the nonprofit medical educational organization, Primary Care Network. Dr. Koffman co-founded and serves as the Chief Medical Officer and EVP of the CLL Society Inc.

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